Research professionals are encouraged to use the contact information on the "Our Team" page of this site to get in touch with members of the NCPC team, or email us at ncpc@northwestern.edu for more information about chemoprevention trials.
Information regarding previous publications and findings can be found in the "Completed Trials" section of our website.
Publications
The Northwestern Cancer Prevention Consortium has been conducting research and publishing their findings since 2003. Check out the links below to view some of our recently published research articles.
Lee O, Xu Y, Akasha AM, Benante K, Blanco L, LaBoy C, Zhang S, Mi X, Helland T, Hustad SS, Gursel DB, Kocherginsky M, Mellgren G, Pilewskie M, Degnim A, Al-Hilli Z, Amin AL, Hwang ES, Guenther JM, Dimond EP, Perloff M, Heckman-Stoddard BM, Khan SA. A pre-surgical window trial of oral tamoxifen versus transdermal 4-hydroxytamoxifen gel in women with estrogen receptor positive duct carcinoma in situ (DCIS). PD15-12. San Antonio Breast Cancer Symposium Annual Meeting. San Antonio, TX, December 2022.
Xu Y, Saiz A, Rimel B, Corr B, Secord AA, Clark LH, Kocherginsky M, Schering T, Benante KA, Kalinichenko K, Sauter E, Samimi G, Dimond E, Khan SA, Barber EL. Surgical window-of-opportunity study of megestrol acetate compared with megestrol acetate and metformin for endometrial intraepithelial neoplasia. American Society of Clinical Oncology Annual Meeting. Virtual Meeting, June 2022.
Samimi G, House M, Benante K, Bengston L, Budd T, Dermody B, DeShong K, Dyer V, Kimler BF, Sahasrabuddhe VV, Siminski S, Ford LG, Vilar E, Szabo E. Lessons Learned from the Impact of COVID-19 on NCI-sponsored Cancer Prevention Clinical Trials: Moving Toward Participant-centric Study Designs. Cancer Prev Res. 2022 May 3;15(5):279-284.
Goodman MT, Lo SK, Yadav D, Wu BU, Jamil LH, Kwok KK, Papachristou GI, Afghani E, Choi-Kuaea Y, Waldron RT, Lombardi C, Jeon CY, Helenowski IB, Richmond E, Benante K, Habtezion A, Schering T, Khan SA, Rodriguez LM, Pandol SJ. A Randomized, Double-Blinded, Placebo-Controlled Trial of Simvastatin to Prevent Recurrent Pancreatitis. Pancreas. 2022 Jan 51-1.
Lee O, Pilewskie M, Karlan S, Tull MB, Benante K, Xu Y, Blanco L, Helenowski I, Kocherginsky M, Yadav S, Hosseini O, Hansen N, Bethke K, Muzzio M, Troester MA, Dimond E, Perloff M, Heckman-Stoddard B, Khan SA. Local transdermal delivery of telapristone acetate through breast skin, compared to oral treatment: a randomized double-blind, placebo-controlled Phase II trial. Clin Pharmacol Ther. 2020 Sep 30. doi: 10.1002/cpt.2041.
Xu L, Zhang Y, Xue X, Liu J, Li J, Yang GY, Ying Song Y, Pan Y, Ma Y, Hu S, Wen A, Jia Y, Rodriguez LM, Tull MB, Benante K, Khan SA, Cao Y, Jovanovic B, Richmond E, Umar A, Bergan R and Wu K. A Phase I Trial of Berberine in Chinese with Ulcerative Colitis. Can Prev Res. 2020 Jan 19-0258.
Alber K, Benante KA, Xu Y, Tull M, Segura AJ, Kalinichenko K, Hou L, Jovanovic B, Perloff M, Heckman-Stoddard BM, Dimond EP, Khan SA. Phase I trial of endoxifen gel versus placebo gel in women undergoing breast surgery. American Society for Clinical Oncology Annual Meeting, June 2019.
Scherr CL, Badal HJ, Xu Y, Benante K, Diamond E, Heckman-Stoddard B, & Khan SA. A pilot test of the impact of an informational animated video on potential participation in a window of opportunity study. Annual Meeting and Scientific Sessions of the Society of Behavioral Medicine, March 2019.
Lee O, Pilewskie M, Xu Y, Benante K, Blanco L, Helenowski I, Tull MB, Muzzio M, Jovanovic B, Karlan S, Hansen N, Bethke K, Kulkarni S, Perloff M, Dimond EP, Heckman-Stoddard BM, Khan SA. Local transdermal therapy (LTT): Drug permeation and distribution of telapristone acetate (TPA) in a pre-surgical window study of women undergoing mastectomy. P6-21-12. San Antonio Breast Cancer Symposium. San Antonio, TX. December 2018.
Lee O, Pilewskie M, Xu Y, Benante K, Blanco L, Helenowski I, Tull MB, Muzzio M, Jovanovic B, Karlan S, Hansen N, Bethke K, Kulkarni S, Perloff M, Dimond EP, Heckman-Stoddard BM, Khan SA. Progesterone receptor (PR) antagonism by telapristone acetate (TPA): A randomized, placebo-controlled phase IIB pre-surgical window trial in women with stage 0-II breast cancer. P5-04-02. San Antonio Breast Cancer Symposium. San Antonio, TX. December 2018.
Alber KM, Murff H, Ness R, Seidner D, Zhu X, Shrubsole M, Tull MB, Benante KA, Segura AJ, Kalinichenko K, Hou L, Jovanovic B, Della'Zanna G, Richmond E, Khan SA, Dai Q. Evaluating intermittent dosing of aspirin for colorectal cancer prevention. June 2018. DOI: 10.1200/JCO.2018.36.15_suppl.TPS1594 Journal of Clinical Oncology 36, no. 15_suppl.
Benante KA, Xu Y, Tull M, Segura AJ, Alber KM, Kalinichenko K, Hou L, Jovanovic B, Perloff M, Heckman-Stoddard BM, Dimond EP, & Khan SA. A phase IIB pre-surgical trial of oral tamoxifen (TAM) versus transdermal 4-hydroxytamoxifen (4-OHT) in women with DCIS of the breast. San Antonio Breast Cancer Symposium Annual Meeting, December 2018.
Benante KA, Xu Y, Tull MB, Segura AJ, Alber KM, Kalinichenko K, Hou L, Jovanovic B, Perloff M, Heckman-Stoddard BM, Dimond EP, Khan SA. A phase IIB pre-surgical trial of oral tamoxifen (TAM) versus transdermal 4-hydroxytamoxifen (4-OHT) in women with DCIS of the breast. June 2018. DOI: 10.1200/JCO.2018.36.15_suppl.TPS1595 Journal of Clinical Oncology 36, no. 15_suppl.
Wali RK, Bianchi L, Kupfer S, De La Crz M, Jovanovic BD, Weber C, Goldberg MJ, Rodriguez LM, Bergan R, Rubin D, Tull MB, Richmond E, Parker B, Khan SA, Roy HK. Prevention of colonic neoplasia with polyethylene glycol: a short term placebo-controlled double-blinded trial. PLoS One. 2018 Apr 4;13(4).
Bradford EM, Thompson CA, Goretsky T, Yang GY, Rodriguez LM, Li L, Barrett TA. Myo-inositol reduces β-catenin activation in colitis. World J Gastroentrol. 2017 Jul 28;23(28):5115-26.
Marshall JR, Burk RF, Ondracek RP, Hill KE, Perloff M, Davis W, Pili R, George S, Bergan RC. Selenomethionine and methyl selenocysteine: multiple-dose pharmacokinetics in selenium-replete men. Oncotarget. 2017 Apr 18;18(16):26312-22.
Roy HK, Turzhitsky V, Wali R, Rodosevich AJ, Jovanovic BD, Della’Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez LM, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V. Spectral markers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 Feb;66(2)2:85-92.
Lee O, Khan SA. Novel routes for administering chemoprevention: Local transdermal therapy to the breasts. Semin Onc. 2016 Feb; 43(1):107-15. PMID: 26970129.
Jovanovic DB, Subramanian H, Helenowski IB, Roy HK, Backman V. Clinical Trial Laboratory Data Nested With in Subject: Components of Variance, Sample Size and Cost. Biom Biostat Int J 2(2): 00029. April 2015. DOI: 10.15406/bbij.2015.02.00029.
Lee O, Page K, Ivanvic D, Helenowski I, Parini V, Sullivan ME, Margenthaler JA, Chatterton RT Jr, Jovanovic BD, Dunn BK, Heckmann-Stoddard BM, Foster K, Muzzio M, Shklovskaya J, Skripkauskas S, Kulesza P, Green D, Hansen NM, Bethke KP, Jeruss JS, Bergan RC, Khan SA. A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast. Clin Cancer Res. 2014 Jul 15;20(14):3672-82.
Wong SJ, Campbell B, Massey B, Lynch DP, Cohen EE, Blair E, Selle R, Shklovskaya J, Jovanovic BD, Skripkauskas S, Dew A, Kulesza P, Parimi V, Bergan RC, Szabo E. A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia. Oral Oncology. 2013 Sep;49(9):970-6.
Lee O, Lazzeroni M, Khan SA. Innovative Approaches to Tamoxifen Administration for Breast Cancer Prevention. In: Tamoxifen Concepts and Cancer New Paradigms, Chap 5. (Ed. de Mello). Nova Biomedical, New York, NY 2013.
Lee O, Khan SA. A Fitting Prescription for All: Whole Soyfoods as Part of a Varied Plant-Based Diet. Oncology (Williston Park). 2013 May;27(5):450, 452, 454.
Dew A, Khan SA, Babinski C, Michel N, Heffernan M, Stephan S, Jordan N, Jovanovic BD, Carney P, Bergan RC. Recruitment strategy cost and impact on minority accrual to a breast cancer prevention trial. Clin Trials. 2013 Apr;10(2):292-9.
Khan SA, Chatterton RT, Michel N, Bryk M, Lee O, Ivancic D, Heinz R, Zalles CM, Helenowski IB, Jovanovic BD, Franke AA, Bosland MC, Wang J, Hansen NM, Bethke KP, Dew A, Coomes M, Bergan RC. Soy isoflavone supplementation for breast cancer risk reduction: a randomized phase II trial. Cancer Prev Res. 2012 Feb;5(2):309-19.
Lee O, Helenowski IB, Chatterton RT Jr, Jovanovic BD, Khan SA. Prediction of menopausal status from estrogen-related gene expression in benign breast tissue. Breast Cancer Res Treat. 2012 Feb;131(3):1067-76.
Marshall JR, Ip C, Romano K, Fetterly G, Fakih M, Jovanovic BD, Perloff M, Cromwell J, Davis W, French-Christy R, Dew A, Coomes M, Bergan RC. Methyl selenocysteine: single-dose pharmacokinetics in men. Cancer Prev Res. 2011 Nov;4(11):1938-44.
Xu L, Wang SS, Healey MA, Faupel-Badger JM, Wilken JA, Battaglia T, Szabo E, Mao JT, Bergan RC. The ninth annual American association for cancer research international conference on frontiers in cancer prevention research. Cancer Prev Res (Phila). 2011 Apr;4(4):616-21.
Mavese JM, Farmer RL, Bergan RC. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev. 2010 Sep;29(3):465-82.