Have you been diagnosed with Lynch Syndrome (LS)?
Lynch Syndrome (LS) increases the risk of colon cancer and can also increase the risk of other cancers, including cancer of the uterus, ovaries, small bowel, stomach, pancreas, urinary tract, skin and brain. Cancer prevention strategies for people with LS are therefore urgently needed. Using vaccines to train the body’s own immune system to prevent polyps and cancers is a new approach that we plan to test in patients with LS.
Testing a combination of vaccines for cancer prevention in Lynch Syndrome
The purpose of this study is to compare the safety and effects of the Tri-Ad5 vaccines alone, or in combination with N-803, versus placebo on the risk of developing colon and other cancers in patients with Lynch syndrome. The Tri-Ad5 vaccines and N-803 are not FDA-approved. This study is looking for volunteers who have been diagnosed with Lynch syndrome. We will enroll 158 participants at institutions across the country.
You may be eligible if:
You have been diagnosed with Lynch syndrome and have had abnormal growths in your colon or rectum
You have not have any cancer treatment in the past 6 months
You are over 18 years of age
You are not pregnant or planning to get pregnant
If you think you may be eligible, you can contact a study coordinator at your preferred location from the list below:
NORTHWESTERN UNIVERSITY– Chicago, Illinois
UNIVERSITY OF COLORADO – Aurora, Colorado
DUKE UNIVERSITY – Durham, North Carolina
CEDARS-SINAI MEDICAL CENTER– Los Angeles, California
UNIVERSITY OF NORTH CAROLINA – Chapel Hill, North Carolina