Have you been diagnosed with Lynch Syndrome (LS)?

Lynch Syndrome (LS) increases the risk of colon cancer and can also increase the risk of other cancers, including cancer of the uterus, ovaries, small bowel, stomach, pancreas, urinary tract, skin and brain. Cancer prevention strategies for people with LS are therefore urgently needed. Using vaccines to train the body’s own immune system to prevent polyps and cancers is a new approach that we plan to test in patients with LS.

 
 

Testing a combination of vaccines for cancer prevention in Lynch Syndrome

The purpose of this study is to compare the safety and effects of the Tri-Ad5 vaccines alone, or in combination with N-803, versus placebo on the risk of developing colon and other cancers in patients with Lynch syndrome. The Tri-Ad5 vaccines and N-803 are not FDA-approved. This study will soon be looking for volunteers who have been diagnosed with Lynch syndrome. We will enroll 158 participants at institutions across the country.

 

You may be eligible if:

  • You have been diagnosed with Lynch syndrome and have had abnormal growths in your colon or rectum

  • You have not had any cancer treatment in the past 6 months

  • You are over 18 years of age

  • You are not pregnant or planning to get pregnant

 

If you think you may be eligible, email ncpc@northwestern.edu to be matched with a study coordinator at one of the following locations:

NORTHWESTERN UNIVERSITY– Chicago, Illinois

UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER– Houston, Texas

UNIVERSITY OF MICHIGAN– Ann Arbor, Michigan

UNIVERSITY OF ARIZONA CANCER CENTER– Tuscon, Arizona

UNIVERSITY OF COLORADO– Aurora, Colorado

UNIVERSITY OF WISCONSIN CARBONE CANCER CENTER– Madison, Wisconsin

UNIVERSITY OF KANSAS MEDICAL CENTER– Kansas City, Kansas

CLEVELAND CLINIC– Cleveland, Ohio

UNIVERSITY OF PUERTO RICO– San Juan, Puerto Rico

OHIO STATE UNIVERSITY– Columbus, Ohio

UNIVERSITY OF UTAH– Salt Lake City, Utah

MAYO CLINIC ROCHESTER– Rochester, Minnesota 

DANA FARBER CANCER INSTITUTE– Boston, Massachusetts

MAYO CLINIC ARIZONA– Phoenix, Arizona

Additional Resources

Coming Soon