Do you have chronic ulcerative colitis?

Patients with ulcerative colitis are at higher than average risk of developing cancer of the large intestine (bowel) or colorectal cancer. Doctors at Northwestern Medicine are doing this study to find out if taking the drug atorvastatin might decrease that risk. We are studying atorvastatin because research suggests that it may interfere with cancer development. Atorvastatin is a cholesterol-lowering drug used to treat cardiovascular disease.


Testing Atorvastatin to lower colon cancer risk in longstanding ulcerative colitis

Principal Investigator: Dr. Guang-Yu Yang and Dr. Stephen Hanauer
Northwestern University

In this study you will receive either 20 mg of atorvastatin, or placebo pills, by mouth once a day for up to one year, in addition to your standard of care. This will allow researchers to see if participants taking atorvastatin show changes in their colon, which may indicate a lower risk of developing cancer. 


After one year of treatment with either atorvastatin or placebo, your study doctor will continue to follow your condition and watch you for side effects for up to 21 days. You should continue your routine yearly surveillance colonoscopy examination.


We will enroll about 70 participants. We are looking for volunteers who:

  • Are between 18 and 70 years of age

  • Have chronic ulcerative colitis (diagnosed at least 8 years ago)


If you think you may be eligible, look for more information here soon. 

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