Do you have 
endometrial intraepithelial neoplasia (EIN)?

Endometrial intraepithelial neoplasia (EIN), also known as Complex Atypical Hyperplasia (CAH), is a change in the lining of the uterus that can lead to cancer of the uterus. Uterine/endometrial cancer is the most common gynecologic cancer and its incidence is increasing rapidly. The usual approach for women diagnosed with EIN/CAH is surgical - hysterectomy (removal of the uterus) without any prior medical treatment with pills. We are doing this study to see if it is possible to treat EIN by changing the lining of the uterus at the cellular level and prevent it from turning into uterine cancer, without doing a hysterectomy.
 

 
 

Megestrol acetate compared with megestrol acetate and metformin to prevent endometrial cancer

Principal Investigator: Emma Barber, MD, MS
Northwestern University

This study will test the effects of megestrol acetate combined with metformin in people with EIN. Participants in this study will get either megestrol acetate, or megestrol acetate and metformin. This will allow researchers to compare the effectiveness of the drug combination in reducing the growth of EIN. This study is looking for volunteers who have been diagnosed with EIN and are planning a hysterectomy. We will enroll 50 participants.

 

You may be eligible if you:

  • Have been diagnosed with endometrial intraepithelial neoplasia or atypical hyperplasia 

  • Are over 18 years of age

 

If you think you may be eligible, you can contact a study coordinator at your preferred location from the list below:

NORTHWESTERN UNIVERSITY– Chicago, Illinois

UNIVERSITY OF COLORADO – Aurora, Colorado

DUKE UNIVERSITY – Durham, North Carolina

CEDARS-SINAI MEDICAL CENTER– Los Angeles, California

UNIVERSITY OF NORTH CAROLINA – Chapel Hill, North Carolina

Additional Resources

Study Brochure