Have you had

colon polyps?

Approximately 1 out of every 18 people develop cancer of the large bowel (colorectal cancer) in their lifetime, and 40% die within 5 years of diagnosis. Although removal of polyps through colonoscopy reduces risk of colorectal cancer, this remains to be one of the most common cancers in the US, and an important cause of cancer death.


Aspirin in Preventing Colorectal Cancer in Patients with Adenoma

Principal Investigator: Dr. Qi Dai
Vanderbilt University

Previous studies have indicated that taking aspirin daily may prevent people who have had polyps from developing colorectal cancer, but it can also cause stomach ulcers or bleeding from the gut. The goal of our study is to test whether taking aspirin on an intermittent schedule (3 weeks on and 3 weeks off) will have the same potentially favorable cancer–preventive effects on the colorectal cell as was indicated in previous daily schedule studies, but avoid the changes that may lead to bleeding or ulcers. The study has three groups:

Group 1: Take a 325 mg pill of aspirin daily for 12 weeks

Group 2: Take a 325 mg pill of aspirin daily for three weeks (weeks 1 – 3), followed by an inactive aspirin look-alike (placebo) pill daily for 3 weeks (weeks 4 – 6), then again take a 325 mg pill of aspirin daily for three weeks (weeks 7 – 9), followed by an inactive  look-alike (placebo) pill daily for 3 weeks (weeks 10 – 12) -  for a total of 12 weeks

Group 3: Take an inactive aspirin look-alike (placebo) pill daily for 12 weeks


They will have rectal biopsies before and after the treatment. We would like to enroll about 90 participants in this study at Vanderbilt University.


You may be eligible if you:

  • Have recently been diagnosed with colon polyps

  • Are 18 or older


If you think you may be eligible, you can contact a study coordinator at Vanderbilt University:



Additional Resources

Study Brochure

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